., 2000). This sparing of CB1 receptors following peripheral nerve injuries could indicate a possible therapeutic benefit of cannabinoids over opioids from the remedy of neuropathic pain. This speculation is more supported by a recent examine (Mao et al
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., 1997). It was verified this impact was mediated from the CB1 receptor and occurred in a dose that was not connected to apparent Unintended effects. This research also shown an increase in thermal hyperalgesia and mechanical allodynia by administration of SR141716a by itself, top the authors to infer the presence of the endogenous tone of cannabinoid analgesia in neuropathy. However, the evidence for this sort of tone all through lionwin55 inflammation is controversial (Beaulieu et al
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